Anti Aging Health and Nutrition

Posts Tagged ‘resveratrol benefits’

At the School of Life Sciences at Lanzhou University, G.A. Liu and R.L. Zheng conducted research into the ability of polyphenols (groups of chemicals found in plants) to protect healthy cells against diseases like heart disease and cancer at the cellular level.

The Study

Seven polyphenols were studied, among them resveratrol.

DNA damage was induced by using hydrogen peroxide on human peripheral blood lymphocytes (PBL) which is known to cause single strand breakage in DNA. The researchers then observed the ability of the seven polyphenols to protect the cells against the damage the hydrogen peroxide was invoking on the cellular DNA.

Resveratrol Provides Significant Cell Protection

Resveratrol, as well as others of the seven tested polyphenols, had a substantial impact on inhibiting cell damage. The impact was dose-dependent as higher doses were more effective in cell protection.

Some of the polyphenols, however, failed to provide any protection. In fact, only three had any effect in protecting the cells against hydrogen peroxide damage (resveratrol, quercetin, and 7.8-dihydroxy-4-methyl coumarin), but these had a big enough impact to convince the researchers that they had discovered a possible mechanism explaining resveratrol’s outstanding track record in protecting against cancer and heart disease.

G. Calabrese of the Department of Human Nutrition at Universita Cattolica in Piacennza, Italy took a close look at the health benefits of moderate red wine consumption as it might impact menopause.

Leading up to this 1999 study, there was a great deal of literature surrounding the health benefits of resveratrol, a polyphenol naturally occurring in many foods and beverages. Its cancer preventative and heart disease preventative characteristics have made resveratrol the focus of many studies. However, Calabrese intended to determine if these health benefits would extend themselves beyond cancer and heart disease and might be an influence on menopause.

Calabrese’s Findings Surrounding Resveratrol

The hypothesis of this study is based on the idea that the structure of resveratrol is so much like that of diethylstilbestrol, a drug prescribed to prevent miscarriages, that it might act as a phytoestrogen in humans.

Calabrese’s team conducted a population study, read literature on resveratrol’s effects on female reproduction, osteoporosis, and cancer, and they conducted various trials of their own.

Conclusion

Their findings concluded that moderate wine consumption appeared to act as a phytoestrogen, a compound in plants that simulates estrogen in humans. Resveratrol boosted the physiological reactions that typically accompany estrogen increases. This activity could effectively moderate the effects and symptoms of menopause in women.

Drs. A.A. Bertelli, L. Giovannini, W. Bemini, M. Migliori, M. Fregoni, L. Bavaresco, and A. Bertelli at the Institute of Anatomy at University of Milan, Italy have evaluated the anti-blood clotting effect of cis-resveratrol, a type of the antiaging compound resveratrol found in red wine.

In 1996, these doctors evaluated the anti-blood clotting activities of cis-resveratrol in a laboratory environment in different concentrations on blood-platelet rich plasma. Cis-resveratrol was able to decrease toxin-induced blood platelet clotting, while trans-resveratrol at the same concentration had a lower efficiency rate. However, both types of resveratrol were observed to cause a decrease in blood clotting, a common condition experienced by aging adults.

In this study, both of these have effective properties in biological fluids, such as blood platelet rich plasma. The evaluation of resveratrol activity in animals and humans takes into account the total amount of both cis- and trans-resveratrol. Cis- and trans-resveratrol, like resveratrol, can be consumed by drinking red wine or taking resveratrol supplements, in the form of tablets, pills or lozenges.